A Physician’s Perspective on Optimal Cannabis Dosing

Dosage is the key factor in achieving the most benefits and least adverse effects of cannabis. After following thousands of patients using medical cannabis for eight years, I’ve observed that dosing cannabis is unlike any therapeutic agent to which I was exposed in my medical training. A basic understanding of the key characteristics of cannabis dosing can empower you to make the most of this incredibly versatile, safe, and effective herb.

Some patients effectively use tiny amounts of cannabis, while others use incredibly high doses. I’ve seen adult patients achieve therapeutic effects at 1 mg of total cannabinoids daily, while others consume over 2,000 mg daily without adverse effects. And while a 2000-fold dosing range is unusual for a medication, researchers have failed to kill monkeys at doses even 300 times higher than the highest dose I’ve observed in the clinic.[i]

Multiphasic Dose-Response Relationships

Within this unusually broad

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